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Cost of metoclopramide, which has become the most commonly used treatment for OCD. However, a new study shows that the long-term efficacy of metoclopramide in treating OCD may be doubt, according to a senior researcher in the study.
The study, conducted on patients with OCD and major depression, shows that after four years of being treated with the drug, majority of patients experienced some improvement in their symptoms. However, the researchers also found that number of OCD patients who reported significant improvement over the four-year period was lower than for those who did not take the drug.
As a result, the researchers estimate that metoclopramide, which is considered to be less effective than other antiepileptics, may not be an effective treatment for OCD. They conclude that "a large proportion of patients with OCD may be suffering from suboptimal treatment outcomes, given the relatively low response rates reported in these studies."
In a statement, Marc Weisskopf, M.D., Ph.D., chair of the Department Psychiatry at University of California, San Francisco, who was not involved in the study, said that this is the first study to compare long-term efficacy of antiepileptics against placebo, suggesting that the long-term results are not always positive.
In the study, published Archives of General Psychiatry, the researchers analyzed medical records of a total 1,064 psychiatric patients with OCD who were treated metoclopramide for four years, from January 1, 2004 to May 2006.
During the course of study, researchers reviewed patients' baseline symptoms and were then
cost of ezetrol in ireland able to determine whether the therapy had a beneficial effect in reducing the severity of their OCD symptoms.
As expected, the researchers found that all of the patients experienced some improvement in their OCD symptoms with the treatment. However, in vast majority of cases, the improvement was only short-lived, and about 10 percent of patients showed a decrease in their symptoms that lasted for more than four years. In addition, only about half of patients had sustained greater improvement over time.
The researchers also examined whether medication treatment was more effective than the placebo in treating OCD. addition, the researchers compared effects of metoclopramide with fluoxetine, which
Atorvastatin 80 mg cena is widely prescribed as a serotonin-reuptake inhibitor and has been shown to be as effective the SSRI in treating OCD.
In this study, the researchers found that there were no significant differences in the effectiveness of metoclopramide and fluoxetine over the four-year period. Instead, researchers found that metoclopramide appeared to have similar efficacy fluoxetine, which was also found to have low long-term effectiveness, and was also comparable with zuclopenthixol, which is another medication that has been reported to be as effective the SSRI.
In a press statement, Dr. Weisskopf said that his team believes "medication treatment of OCD is likely to be less effective and more costly than the standard treatment of cognitive behavioral therapy in the general population."
He urged clinicians to focus on treating OCD symptoms, rather than trying
Ezetrol 180 Pills $126 - $115 Per pill to prevent or minimize them.
"It's best to treat this condition head-on with the help of a professional," Weisskopf said. "But, if you're not sure going to have success or not, then taking a small dose of one these drugs could be a valuable thing."
In the statement, Dr. David Kupfer, M.D., of the University California, San Francisco, said that "our results suggest the long-term effectiveness of medication treatment OCD is likely to be less than for cognitive therapy. This should not discourage clinicians from trying these newer treatments."
The researchers also note that "even though the data in favor of medication treatment were modest, the data in favor of cognitive-behavior therapy treatment were generally superior to the results from our study."
In addition, the researchers say that because they did not have enough time to track patient safety, they cannot determine whether long-term effectiveness of either medication was reduced by the side effects of medication.
According to Dr. Kupfer, "It is important to note that we did not find any evidence that medication treatment was either necessary for outcomes or that patients who took medications experienced increased adverse effects."
Kathy W. Smith, M.D., director of the Center for Women's Mental Health at the University of Washington in Seattle, who was not involved with
ezetrol price australia the study, noted that "the results of the current study should be interpreted with caution. Nonetheless, the findings lend support to hypothesis
Buy buspar uk that the clinical utility of SSRIs [selective serotonin reuptake inhibitors], particularly fluoxetine, is unclear at this time."
Dr. Smith added, "I would caution clinicians"
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