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Trazodone in uk raine. 1) A very important study by Dr. Robert B. Schulenberg (New York State Psychiatric Institute, NY, USA) published in 1975 the scientific journal Psychiatric Research: first clinical study of the effects trazodone in acute bipolar depression. The authors reported a significant reduction in the number of manic episodes in patients treated with trazodone, compared a placebo (N=15). According to the same authors, antidepressant effect of trazodone was also verified in a controlled, double-blind study six patients with acute bipolar depression. These results have been confirmed by Dr. B. J. Williams of the Department Psychiatry, Clinical Psychology, and School of Medicine, University South California, Los Angeles, USA, in his detailed study of trazodone in bipolar depressives (Williams and Bienenstock, 1975). 2) A second study published in 1978 by Dr. J. V. Beech and colleagues at the University of Illinois Chicago, reported a significant reduction in the number of manic episodes with trazodone, compared placebo. In eight patients with a history of manic episodes, trazodone significantly reduced the numbers of manic episodes (N=19). In their further analyses, Beech and colleagues reported that trazodone was more effective than lithium and aripiprazole in this treatment. 3) The third study (Beech and colleagues, 1978) was undertaken at the University of South California, Los Angeles with bipolar patients (mean age 38.8 ﾂｱ 10.9 years; 5 female, 4 male) who were taking trazodone. In this study a total of 39 patients were randomly assigned to trazodone (12 patients