Generic paroxetine vs paxil ), not because of lack benefit, but safety" (Rudolf et al., 2005). In a 2005 Cochrane review of trials paroxetine and plus risperidone, paxil, sertraline, escitalopram, venlafaxine and plus clomipramine, it was noted that the overall numbers of treatment-reported deaths, and all-cause mortality, were statistically clinically comparable between paroxetine and placebo (Rao, 2005). On the other hand, another study (Ponca et al., 2004) suggested that if paroxetine was used with benzodiazepines (and particularly, diazepam or lorazepam), it was of "potentially little or no benefit for long-term treatment that consists of multiple doses a short-acting benzodiazepine with extended-release medications", while concomitantly increasing the risk of mortality.
Paroxetine Dormidina 125mg $179.15 - $0.66 Per pill may also increase sexual problems. A review published in 2005 found that of 14,845 adult male patients with a paraphilia (that is, unusual arousal associated with sexual desire and behavior), about 10% (n=4,700) used a psychoactive medication (n=1,938). Half of them were using a selective serotonin reuptake inhibitor (SSRI), and more than 70% (4444/6148) were found to have used paroxetine. Similar results were seen in a review published 2000 of 15,082 adult male psychiatric inpatients treated for sexual arousal/desire disorder. Of these, 2114 (36%) patients had taken paroxetine and of them (n=1,732) 1123 were found to have used SSRIs. Also, 609 patients were found to have taken drowsiness agents, and in almost half of these cases (441), paroxetine was the SSRI. While these results indicate that paroxetine may increase the likelihood that patients with sexual arousal disorder will become sexually involved with others, the data are not definitive as they do account for whether paroxetine might worsen other aspects of their psychological distress such as depression or anxiety. And, despite the apparent association of SSRIs with sexual dysfunction, studies have suggested that SSRI use in the context of sexual dysfunction may not make a person with that diagnosis more inclined to have an actual homosexual or bisexual relationship (Sajdel-Sulkowska and Schacht, 2004). Thus, given that paroxetine is widely recognized as a useful treatment for wide range of sexual disorders (e.g., ED), the question is whether such effects do extend to sex between an SSRI or other combination of drugs/lifestyle and substance abusers, as well those who have been on an SSRI for over a year.
The issue surrounding link between SSRI treatment and sexual harm seems not to apply non-medical users of paroxetine. A study published in 2007 using the National Adult Reading Test (NART) found that of 682 recreational users paroxetine over a 12-year period (1999-2007), only 6.2% (n=47) had reported experiencing difficulty or distress due to adverse reactions the medicine. At time study was conducted, paroxetine used in high prevalence the US, and had recently been approved for the treatment of some adults with psychiatric conditions such as depression, generalized anxiety disorder and social anxiety. However, in terms of how often paroxetine has been prescribed, and as to whether this had ever led to problems for subjects, there was poor information that could permit a conclusive answer to this question.
Conclusion
In the USA, paroxetine is currently being used extensively for the treatment of treatment-resistant depression and/or for general anxiety disorder. Paroxetine has not been linked with abuse-related harms, although the safety information is not yet adequate to identify all situations where paroxetine abuse might occur or other adverse events could occur. It is possible that abuse of paroxetine may occur by the following means:
persisting excessively to a degree that is excessive to any potential benefit, or causing harmful consequences.
intentionally or unintentionally using the medicine in an unusual manner and for inappropriate purpose, in the presence of others, at doses or in the manner of others.
repetitive interactions between paroxetine and other pharmaceuticals or compounds, in ways that increase the susceptibility of patient to side effects the treatment.
repetitive dosage regimens, as demonstrated by decreased effect in response to subsequent doses taken once the initial dose has been exhausted.
possible long-term use in combinations with certain other psychotropic medications, leading to higher rates of discontinuation than a standard monophasic agent.
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