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A new study by research group in the Department of Pharmaceutical Sciences at The University of North Carolina, Chapel Hill, suggests the effectiveness of colchicine could possibly be increased by further development of synthetic and natural versions.
The study involved development of clobetasol citrate (CC), a new oral treatment Cialis buy australia online
for people who receive colchicine colchicine cost without insurance at high doses or use it for a prolonged or period. The research was supported by Colchicine 0.5mg $159.56 - $0.59 Per pill
US Department of Defense. Further details the study were reported in April issue of the Journal American Pharmacists Association.
The NC Pharmaceutical Sciences team conducted a randomized, controlled study to test how the use of CC might affect the rate of relapse when patients switch, or discontinue, use of colchicine. The study was conducted in collaboration with the Veterans Administration (VA) and conducted by Dr. Richard Bloss, PharmD, Senior, School of Pharmacy and Pharmaceutical Sciences, colleagues. The researchers used a random allocation procedure, with participants receiving a placebo or CC, and then followed them for 6 weeks to determine relapse rates.
Patients switched from colchicine to CC were given a 2-week washout period between study visits prior to receiving the new treatment. Additionally, researchers conducted a total of 33 patients discontinuing use colchicine were matched to 33 controls for age, sex, baseline dose, and presence or absence of colchicine-associated symptoms.
A total of 37% the experimental group patients relapsed of the colchicine-associated symptoms, compared to only 17% of the control group patients, and these relapse rates were higher with the CC group, 28% relapsing to colchicine-associated symptoms in the CC group compared to 5% in the control group. Clobetasol citrate also reduced colchicine-associated symptoms in 26.7% of the experimental group patients, compared to 8% of the controls.
Despite these findings, Dr. Bloss and colleagues found that there were no significant differences in the total number of medications used in all groups of patients.
"We found that when patients were switched between anticoagulation agents, they were more likely to discontinue colchicine than their respective control patients," explained Dr. Bloss, research fellow in the Department of Pharmaceutical Sciences. "That is interesting, but since other oral antiplatelet chemotherapeutics offer similarly enhanced anticlotting benefits to colchicine, we want examine the potential of other natural products as adjunctive therapies for colchicine."
Dr. Bloss believes that if further research on other natural products is conducted, there might be room to investigate the use of these agents for anticoagulation. "With a natural product, we would have no active ingredient to remove from the diet. And, we also have to consider the potential of improved absorption and the potential for better tolerability and fewer side effects with more potent treatment regimens."
For more information, please see the UPharm site at http://www.psychology.unt.edu/public/healthpolicy/Pages/clinical-trials.aspx.
This is a summary of study published in the Journal of.
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